• World J Gastroentero · Dec 2005

    Case Reports

    Does Fasciola hepatica infection modify the response of acute hepatitis C virus infection to IFN-alpha treatment?

    • Mehmet Sahin, Mehmet Isler, Altug Senol, Mustafa Demirci, and Zeynep Dilek Aydin.
    • Department of Internal Medicine, Suleyman Demirel University, School of Medicine, Isparta, Turkey. mehmetsahin66@hotmail.com
    • World J Gastroentero. 2005 Dec 28;11(48):7688-9.

    AbstractImmunologic response to acute hepatitis C is mainly a Th1 response, whereas fasciolopsiasis is associated with a diverse T-cell response. Interferon-alpha has immunomodulatory effects and enhances Th1 immune response. Fasciola infection could theoretically interfere with the Th1 immune response, even when acquired after an initial response to interferon-alpha treatment for acute hepatitis C virus (HCV) infection. We report here the case of a male patient who acquired Fasciola hepatica infection after an initial response to IFN-alpha therapy with a favorable outcome.

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