• Manoel Jacobsen Teixeira, Luciana Mendes Bahia Menezes, Valquiria Silva, Ricardo Galhardoni, José Sasson, Massako Okada, Kleber Paiva Duarte, Lin T Yeng, and Daniel Ciampi de Andrade.
• Departamento de Neurologia, Universidade de São Paulo, Sao Paulo, SP, Brazil.
• Arq Neuropsiquiatr. 2015 Mar 1;73(3):237-40.

UnlabelledTopical treatments have gained popularity for general use as an adjunct to systemic drugs in neuropathic pain, but their use produces variable clinical results and local adverse events.ObjectiveTo evaluate the safety and analgesic effect of a formulation of liposomal capsaicin (LC) (0.025%) in patients with post herpetic neuralgia (PHN).MethodPatients who remained symptomatic after first-and second-line treatment were randomized to receive LC for six weeks in a placebo-controlled, crossover design study. Clinical assessment was performed at baseline, in the second, fourth and sixth week of treatment.ResultsThirteen patients completed both treatment periods. Visual Analog Scale (VAS) was significantly decreased after the end of the study (p = 0.008), however the effect of treatment was not significant (p = 0.076). There was no difference on global impression of change and other pain characteristics. LC was safe and well tolerated. However, at the concentration used, its analgesic effects were marginal and not significant.

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