• Expert Rev Clin Immunol · Jun 2013

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    Rescue therapy: ciclosporin or infliximab?

    • Fernando Rizzello, Chiara Praticò, Carlo Calabrese, and Paolo Gionchetti.
    • Inflammatory Bowel Disease Unit, Dipartimento di Scienze Mediche e Chirurgiche-DIMEC, Ospedale Sant'Orsola-Malpighi, University of Bologna, via Massarenti 9, Bologna 40138, Italy. fernando.rizzello@unibo.it
    • Expert Rev Clin Immunol. 2013 Jun 1;9(6):503-5.

    AbstractSevere active refractory ulcerative colitis is a potentially life-threatening disease. The introduction of intensive steroid treatment and early surgery has reduced mortality in recent years. Ciclosporin and infliximab are effective rescue therapies in steroid refractory colitis. A head-to-head study proposed by Laharie et al. failed to demonstrate the superiority of ciclosporin but confirmed the efficacy and safety of infliximab to control active disease and to maintain remission.

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