• J. Korean Med. Sci. · Oct 2009

    Randomized Controlled Trial

    Antihistamine pretreatment to reduce incidence of withdrawal movement after rocuronium injection.

    • Ho Jun Lee, Sung Jin Han, Heezoo Kim, Il Ok Lee, Myoung Hoon Kong, Nan Suk Kim, Sang Ho Lim, and Mi Kyoung Lee.
    • Department of Anesthesiology and Pain Medicine, Guro Hospital, Korea University College of Medicine, Seoul, Korea.
    • J. Korean Med. Sci. 2009 Oct 1;24(5):879-82.

    AbstractThe purpose of this study was to determine the effectiveness of antihistamine therapy for withdrawal movements caused by rocuronium injection. One hundred seventy one ASA I-II adults undergoing elective surgery were randomly assigned to one of two groups. Patients in the control group (Group C) were premedicated with 2 mL normal saline, and those in the antihistamine group (Group A) were pre-medicated with 2 mL (45.5 mg) pheniramine maleate. After the administration of thiopental sodium 5 mg/kg, rocuronium 0.6 mg/kg was injected. Withdrawal movements were assessed using a four-grade scale. The administration of antihistamine reveals lower grade of withdrawal movement after rocuronium injection.

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