• Blood · Oct 2010

    Review

    Systematic review and meta-analysis methodology.

    • Mark Crowther, Wendy Lim, and Mark A Crowther.
    • Department of Haematology, Worcestershire Royal Hospital, Worcester, United Kingdom. crowthrm@mcmaster.ca
    • Blood. 2010 Oct 28;116(17):3140-6.

    AbstractSystematic reviews and meta-analyses are being increasingly used to summarize medical literature and identify areas in which research is needed. Systematic reviews limit bias with the use of a reproducible scientific process to search the literature and evaluate the quality of the individual studies. If possible the results are statistically combined into a meta-analysis in which the data are weighted and pooled to produce an estimate of effect. This article aims to provide the reader with a practical overview of systematic review and meta-analysis methodology, with a focus on the process of performing a review and the related issues at each step.

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