• Nature neuroscience · Aug 2012

    Comparative Study

    Corticostriatal functional connectivity predicts transition to chronic back pain.

    • Marwan N Baliki, Bogdan Petre, Souraya Torbey, Kristina M Herrmann, Lejian Huang, Thomas J Schnitzer, Howard L Fields, and A Vania Apkarian.
    • Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
    • Nat. Neurosci. 2012 Aug 1;15(8):1117-9.

    AbstractThe mechanism of brain reorganization in pain chronification is unknown. In a longitudinal brain imaging study, subacute back pain (SBP) patients were followed over the course of 1 year. When pain persisted (SBPp, in contrast to recovering SBP and healthy controls), brain gray matter density decreased. Initially greater functional connectivity of nucleus accumbens with prefrontal cortex predicted pain persistence, implying that corticostriatal circuitry is causally involved in the transition from acute to chronic pain.

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