• Pain Res Manag · Sep 2011

    Review

    Nonpharmacological management of procedural pain in infants and young children: an abridged Cochrane review.

    • Rebecca Pillai Riddell, Nicole Racine, Kara Turcotte, Lindsay Uman, Rachel Horton, Laila Din Osmun, Sara Ahola Kohut, Jessica Hillgrove-Stuart, Bonnie Stevens, and Diana Lisi.
    • Department of Psychology, York University, Toronto, Ontario, Canada. rpr@yorku.ca
    • Pain Res Manag. 2011 Sep 1;16(5):321-30.

    BackgroundAcute pain and distress during medical procedures are commonplace for young children.ObjectiveTo assess the efficacy of nonpharmacological interventions for acute procedural pain in children up to three years of age.MethodsStudy inclusion criteria were: participants <3 years of age, involved in a randomized controlled or crossover trial, and use of a 'no treatment' control group (51 studies; n=3396). Additional studies meeting all criteria except for study design (eg, use of active control group) were qualitatively described (n=20).ResultsFor every intervention, data were analyzed separately according to age group (preterm-born, term-born neonate and older infant ⁄ young child) and type of pain response (pain reactivity, immediate pain-related regulation). The largest standardized mean differences (SMD) for pain reactivity were as follows: sucking-related interventions (preterm: -0.42 [95% CI -0.68 to -0.15]; neonate -1.45 [CI -2.34 to -0.57]), kangaroo care (preterm -1.12 [95% CI -2.04 to -0.21]), and swaddling ⁄ facilitated tucking (preterm -0.97 [95% CI -1.63 to -0.31]). For immediate pain-related regulation, the largest SMDs were: sucking-related interventions (preterm -0.38 [95% CI -0.59 to -0.17]; neonate -0.90 [CI -1.54 to -0.25]), kangaroo care 0.77 (95% CI -1.50 to -0.03]), swaddling ⁄ facilitated tucking (preterm -0.75 [95% CI -1.14 to -0.36]), and rocking ⁄ holding (neonate -0.75 [95% CI -1.20 to -0.30]). The presence of significant heterogeneity limited confidence in nonsignificant findings for certain other analyses.ConclusionsAlthough a number of nonpharmacological treatments have sufficient evidence supporting their efficacy with preterm infants and healthy neonates, no treatments had sufficient evidence to support efficacy with healthy older infants ⁄ young children.

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