• Gan To Kagaku Ryoho · Dec 2013

    Case Reports

    [A case of metastatic colorectal cancer with hyperammonemic encephalopathy induced by 5-FU in a patient continuously treated with XELOX therapy].

    • Eriko Nakano, Michio Kuroki, Nana Kanno, Yoshifumi Matsumura, Atsushi Miura, Yoshifumi Kikuchi, and Hidetoshi Hirakawa.
    • Dept. of Gastroenterology, Yamagata City Hospital Saiseikan.
    • Gan To Kagaku Ryoho. 2013 Dec 1;40(13):2581-4.

    AbstractWe report a rare case of a patient with metastatic colorectal cancer who experienced hyperammonemic encephalopathy induced by 5 -fluorouracil(5-FU)and was continuously treated with capecitabine plus oxaliplatin(XELOX)therapy. A 60 years man with anorexia and weight loss was diagnosed with Stage IV rectal cancer, and chemotherapy with XELOX was initiated. When the second course of XELOX therapy was administered, the patient found it difficult to take oral capecitabine. Subsequently, modified FOLFOX6 was administered. Complications such as nausea and vomiting were observed on day 2, with confusion and cognitive disturbances on day 3 . Laboratory examination revealed hyperammonemia, and therefore, branched-chain amino acid solutions were administered as treatment. The patient's symptoms disappeared entirely on day 4. He is currently receiving XELOX therapy.

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