• Methodist Debakey Cardiovasc J · Jul 2011

    Review

    Biology of aortic aneurysms and dissections.

    • Joseph S Fernandez-Moure, Daynene Vykoukal, and Mark G Davies.
    • Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, USA.
    • Methodist Debakey Cardiovasc J. 2011 Jul 1;7(3):2-7.

    AbstractThe biology of aortic aneurysm and dissection has evolved to where we now understand the genetic implications of changes in extracellular matrix proteins, smooth muscle cells, and growth factors and how they affect aortic wall homeostasis. These predeterminants are influenced by smoking, hypertension, and atherosclerosis, and the result in an inflammatory response coupled to an accelerated proteolytic cascade that disrupts both elastin and collagen in the aortic wall.

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