• Steven Z George, Giorgio Zeppieri, Anthony L Cere, Melissa R Cere, Michael S Borut, Michael J Hodges, Dalton M Reed, Carolina Valencia, and Michael E Robinson.
• Department of Physical Therapy, University of Florida, Health Science Center, Gainesville, P.O. Box 100154, FL 32610-0154, USA Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA Department of Physical Therapy, SHANDS Rehab, Gainesville, FL, USA.
• Pain. 2008 Nov 15; 140 (1): 145-157.

AbstractPsychological factors consistent with fear-avoidance models are associated with the development of chronic low back pain (LBP). As a result, graded activity (GA) and graded exposure (GX) have been suggested as behavioral treatment options. This clinical trial compared the effectiveness of treatment-based classification (TBC) physical therapy alone to TBC augmented with GA or GX for patients with acute and sub-acute LBP. Our primary hypothesis was that GX would be most effective for those with elevated pain-related fear. In total, 108 patients enrolled in this clinical trial and were randomly assigned to receive TBC, GA, or GX. Outcomes were assessed by a blinded evaluator at 4 weeks and by mail at 6 months. The primary outcomes for this trial were disability and pain intensity, and the secondary outcomes were fear-avoidance beliefs, pain catastrophizing, and physical impairment. There were no differences in 4-week and 6-month outcomes for reduction of disability, pain intensity, pain catastrophizing, and physical impairment. GX and TBC were associated with larger reductions in fear-avoidance beliefs at 6 months only. Six-month reduction in disability was associated with reduction in pain intensity, while 6-month reduction in pain intensity was associated with reductions in fear-avoidance beliefs and pain catastrophizing. This trial suggests that supplementing TBC with GA or GX was not effective for improving important outcomes related to the development of chronic LBP.

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