• Shanghai Kou Qiang Yi Xue · Jun 2003

    Randomized Controlled Trial Clinical Trial

    [Study of midazolam for premedication in oral and maxillofacial surgery].

    • Hong Jiang, Ying Zhu, Xu Wang, and Ye-sen Zhu.
    • Department of Anesthesiology, Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China.
    • Shanghai Kou Qiang Yi Xue. 2003 Jun 1;12(3):170-3.

    ObjectiveTo study the effects of midazolam for premedication in oral-maxillofacial surgery.Methods60 patients were selected and divided into 3 groups equally with 20 cases in each group. Different drugs were used for premedication. Group received midazolam 0.06 mg/kg, group received diazepam 0.12 mg/kg, group received luminal 3 mg/kg, Intramuscular injections of drugs were finished before 30 minutes of anesthesia. The sedative and anxiolytic effects, the changes of circulation and respiration and the side effects were evaluated.ResultsIn group, BIS (bispectral analysis of electroencephalogram) decreased obviously and Ramsay score increased significantly 5 minutes after drug administration, AVAT(Anxiety visual analog test) and SAI(State anxiety inventory) decreased obviously 30 minutes after administration drug (P < 0.05). But no significant changes in the other groups (P > 0.05). There were no remarkable changes of circulation and respiration in the three groups. No severe side effects were observed after premedication.ConclusionThe premedication of using midazolam has good sedative and anxiolytic effects and few side effects.

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