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- C Sochala, D Deenen, A Ville, and M J Govaerts.
- Clinic of Paediatric Anaesthesia, University Children's Hospital, Queen Fabiola, Brussels, Belgium.
- Paediatr Anaesth. 1999 Jan 1;9(4):349-51.
AbstractWe present the case of a nine-year-old boy afflicted with Ondine's curse, who developed complete atrioventricular heart block after a single bolus of propofol for induction of anaesthesia for strabismus surgery. Ondine's curse, the other name for congenital central hypoventilation syndrome, is characterized by a generalized disorder of autonomic function. Propofol has no effect on the normal atrioventricular conduction system in humans but it reduces sympathetic activity and can highly potentiate other vagal stimulation factors. Heart block has been documented after propofol bolus use in adults but, to our knowledge, not in children. It would appear that propofol is not a good choice for anaesthesia in congenital central hypoventilation syndrome.
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