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Eur. J. Clin. Microbiol. Infect. Dis. · Aug 2012
Aerosolized amikacin in patients with difficult-to-treat pulmonary nontuberculous mycobacteriosis.
- A Safdar.
- Anderson Cancer Center, Houston, TX, USA. amar.safdar@nyumc.org
- Eur. J. Clin. Microbiol. Infect. Dis. 2012 Aug 1;31(8):1883-7.
AbstractPatients with pulmonary nontuberculous mycobacteriosis (pNTM) may have suboptimum response to conventional antimicrobial therapy. Aerosolized amikacin (aeAmk) was given to nine patients who had failed standard combination oral antimycobacterial drugs. A favorable toxicity profile, even in patients given aeAmk for an extended duration, median 75 ± 85 (range, 18-277) days and total cumulative dose 35,400 ± 30,568 (range, 7,600-95,400) mg, was encouraging, as was the clinical response and resolution of symptoms in 8 of 9 patients. The patient who failed therapy died due to complications arising from prior hematopoietic transplantation. The feasibility and efficacy of aeAmk in combination with oral anti-NTM drug(s) for treatment-refractory disease and, importantly, in primary therapy for pNTM requires validation randomized trials.
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