• Nan Fang Yi Ke Da Xue Xue Bao · Mar 2010

    [Pharmacokinetics and pharmacodynamics of poly (lactide-co-glycolide) microspheres containing ropivacaine and dexamethasone for sciatic nerve block in mice].

    • Rang-hui Yu, Zhong-qing Chen, Hui Chen, Wei-jun Fu, and Yan Xu.
    • Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, China. yuranhui7706@yahoo.cn
    • Nan Fang Yi Ke Da Xue Xue Bao. 2010 Mar 1;30(3):502-5.

    ObjectiveTo investigate the pharmacokinetics and pharmacodynamics of poly (lactide-co-glycolide) microspheres containing ropivacaine and dexamethasone for sciatic nerve block in mice.MethodsA total of 165 female mice were randomly assigned into 3 groups, namely dexamethasone-loaded ropivacaine microsphere group (group A, n=55), ropivacaine microsphere group (group B, n=55) and PLGA microsphere group (group C, n=55). The mice received surgical implantation of the corresponding preparations near the sciatic nerve at the dose of 400 mg/kg. Hot plate test was used to evaluate the anesthetic effect of these microspheres at different time points after the implantation, and high-performance liquid chromatography (HPLC) was employed to determine plasma ropivacaine concentration.ResultsPharmacodynamic study showed that the duration of sciatic nerve sensory block was significantly longer in group A than in group B (P<0.05). The analysis of pharmacokinetics variables demonstrated that T(1/2) in group A was prolonged as compared with that of group B. No anesthetic effect was observed in group C.ConclusionDexamethasone-loaded ropivacaine microspheres can significantly prolong the analgesic effect of ropivacaine in mice.

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