• Zhiyu Geng, Guojin Shan, Linlin Song, Xing Xu, and Xinmin Wu.
• Department of Anesthesiology, Peking University First Hospital, Beijing 100034, China. genzy8020@sina.com.cn
• Beijing Da Xue Xue Bao. 2003 Oct 1;35(5):549-52.

ObjectiveTo evaluate the clinical profile of target-controlled infusion-based anesthesia using remifentanil and propofol.Methods16 ASA I-II patients undergoing elective laparoscopic cholecystectomy were enrolled. Remifentanil was set at 7 micrograms.L-1 as target and profol at 3 mg.L-1 throughout the whole procedure. The hemodynamics during induction of anesthesia and recovery profiles were recorded. Arterial blood samples for analysis of remifentanil were taken 15 min after infusion, 20 min after infusion and at time of emergence.ResultsAfter induction of anesthesia, systolic blood pressure (SBP) decreased from (144 +/- 27) mm Hg to (101 +/- 18) mm Hg (P < 0.05), mean blood pressure (MBP) decreased from (102 +/- 15) mm Hg to (69 +/- 13) mm Hg (P < 0.05) and heart rate (HR) decreased from (77 +/- 14) beats.min-1 to (63 +/- 12) beats.min-1 (P > 0.05). SBP, MBP and HR remained stable after intubation for 3 min. No patient showed haemodynamic stress to tracheal intubation. Times from stopping administration of anesthetics until full spontaneous respiration, eye opening, tracheal extubation, orientation and discharging from the postanesthetic care unit (PACU) were (12 +/- 6), (9 +/- 4), (13 +/- 6), (15 +/- 5) and (19 +/- 7) min respectively. Measured drug values of remifentanil were (4.6 +/- 9.5) microgram.L-1, (6.6 +/- 11.5) microgram.L-1, (1.2 +/- 8.7) microgram.L-1 respectively.ConclusionRemifentanil/propofol TCI-based anesthesia achieved the optimal hemodynamic stability during anesthesia induction and maintenance, and better recovery profile from anesthesia. Measured drug values of remifentanil showed a considerable interindividual variation and more lower than the set target.

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