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- Dionysis Papadatos-Pastos, Aspasia Soultati, and Mark Harries.
- Medical Oncology Department, Guy's and St Thomas' NHS Foundation Trust, UK.
- Biomed Res Int. 2013 Jan 1;2013:186563.
AbstractPatients with brain metastases from malignant melanoma historically have a very poor outcome. Surgery and radiotherapy can be used, but for the majority of patients the disease will progress quickly. In the recent past, patients with brain metastases derived only minimal benefit from cytotoxic chemotherapy. Novel therapies that have been shown to be superior to chemotherapy in metastatic melanoma have made their way in clinic and data regarding their use in patients with treated or untreated brain metastases are encouraging. In this paper we describe the use of vemurafenib, dabrafenib, and ipilimumab in patients with melanoma disseminated to the brain in addition to other treatments currently in development.
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