• Kiyonobu Ueno, Yoko Kusunoki, Fumio Imamura, Mana Yoshimura, Suguru Yamamoto, Junji Uchida, and Yoshitane Tsukamoto.
• Department of Pulmonary Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan. ueno-ki@mc.pref.osaka.jp
• Respiration. 2007 Jan 1;74(3):304-8.

BackgroundIt is important to detect preinvasive bronchial lesions before they become invasive cancer, because detection of early cancer is expected to lead to a cure. Autofluorescence bronchoscopy is a useful device in the detection of preinvasive and cancerous lesions. Recently, a new autofluorescence bronchoscopic system, autofluorescence imaging (AFI) system, has been developed.ObjectivesWe evaluated the efficacy of AFI in the diagnosis of precancerous and cancerous lesions.MethodsA total of 31 patients underwent both conventional white-light bronchoscopy (WLB) and AFI from January 2002 to September 2004. We evaluated autofluorescence findings using a four-point scale: AFI-I, II, III, and B. The findings in WLB were evaluated on a three-point scale: WLB-I, II, and III. Abnormal areas by WLB and AFI were biopsied for histopathological examinations.ResultsA total of 64 lesions were evaluated. When the AFI-III finding was regarded as positive in AFI and WLB-III as positive in WLB, sensitivity for severe dysplasia or worse was 94.7% with AFI and 73.7% with WLB, respectively.ConclusionsAFI is an effective system for the detection of precancerous and cancerous lesions.(c) 2006 S. Karger AG, Basel.

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