• Postgraduate medicine · Feb 2001

    The intensive care unit in antimicrobial resistance.

    • M H Koleff.
    • Department of Internal Medicine, Pulmonary and Critical Care Division, Washington University School of Medicine, 660 S Euclid Ave., St Louis, MO 63110, USA. kollefm@msnotes.wustl.edu
    • Postgrad Med. 2001 Feb 1;109(2 Suppl):60-9.

    AbstractMany pressures play a role in escalating the emergence of antibiotic-resistant infections in intensive care units (ICUs), oncology and bone marrow transplant wards, and dialysis units. One is horizontal cross-transmission of antibiotic-resistant infections; another is the frequent use of broad-spectrum antibiotics. Among the serious infections acquired by patients in ICUs are bloodstream infections and nosocomial pneumonia. This article discusses potential multidisciplinary interventions to prevent bacterial resistance. Among these wide-ranging strategies are adequate decontamination between patient contacts, antibiotic guidelines to limit unnecessary use, and use of combination antimicrobial therapy.

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