• Der Anaesthesist · May 2007

    Case Reports

    [Cardiotoxic and neurotoxic effects after accidental intravascular bupivacaine administration. Therapy with lidocaine propofol and lipid emulsion].

    • C Zimmer, K Piepenbrink, G Riest, and J Peters.
    • Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Deutschland. christian.zimmer@uk-essen.de
    • Anaesthesist. 2007 May 1;56(5):449-53.

    AbstractAccidental intravascular administration of bupivacaine can cause severe neurotoxic and cardiotoxic effects. We report a case of suspected bupivacaine intoxication due to intravascular injection via an epidural catheter and treatment with lidocaine, propofol, and a 20% lipid emulsion resulting in fast resolution of cardiotoxic and neurotoxic effects. Possible mechanisms of action of the medications used are discussed.

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