• Wei Zhu, Yan Wu, Ding Xu, Yan-Hong Li, Ba Jun, Xiao-Long Zhang, Fang Wang, and Jing Yu.
• Department of Ophthalmology, Affiliated Tenth People's Hospital of Tongji University, Shanghai, China.
• Plos One. 2013 Jan 1;8(3):e58821.

BackgroundAge-related macular degeneration (AMD) is the main cause of blindness and the curative options are limited. The objective of this meta-analysis was to determine the association between aspirin use and risk of AMD.MethodsA comprehensive literature search was performed in PubMed, Embase, Web of Science, and reference lists. A meta-analysis was performed by STATA software.ResultsTen studies involving 171,729 individuals examining the association between aspirin use and risk of AMD were included. Among the included studies, 2 were randomized-controlled trials (RCTs), 4 were case-control studies and 4 were cohort studies. The relative risks (RRs) were pooled using a random-effects model. Relative risks with 95% confidence intervals (CIs) of aspirin use as a risk for AMD. The pooled RR of 10 included studies between the use of aspirin and risk of AMD was 1.09 (95% CI, 0.96-1.24). The same result was detected in early and late stage AMD subgroup analysis. In the subgroup analyses, the pooled RR of RCTs, case-control studies and cohort studies were 0.81 (95% CI, 0.64-1.02), 1.02 (95% CI, 0.92-1.14) and 1.08 (95% CI, 0.91-1.28), respectively.ConclusionsThe use of aspirin was not associated with the risk of AMD.

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