• Edward Fottrell, Kishwar Azad, Abdul Kuddus, Layla Younes, Sanjit Shaha, Tasmin Nahar, Bedowra Haq Aumon, Munir Hossen, James Beard, Tanvir Hossain, Anni-Maria Pulkki-Brannstrom, Jolene Skordis-Worrall, Audrey Prost, Anthony Costello, and Tanja A J Houweling.
• Institute for Global Health, University College London, England.
• JAMA Pediatr. 2013 Sep 1;167(9):816-25.

ImportanceCommunity-based interventions can reduce neonatal mortality when health systems are weak. Population coverage of target groups may be an important determinant of their effect on behavior and mortality. A women's group trial at coverage of 1 group per 1414 population in rural Bangladesh showed no effect on neonatal mortality, despite a similar intervention having a significant effect on neonatal and maternal death in comparable settings.ObjectiveTo assess the effect of a participatory women's group intervention with higher population coverage on neonatal mortality in Bangladesh.DesignA cluster randomized controlled trial in 9 intervention and 9 control clusters.SettingRural Bangladesh.ParticipantsWomen permanently residing in 18 unions in 3 districts and accounting for 19 301 births during the final 24 months of the intervention.InterventionsWomen's groups at a coverage of 1 per 309 population that proceed through a participatory learning and action cycle in which they prioritize issues that affected maternal and neonatal health and design and implement strategies to address these issues.Main Outcomes And MeasuresNeonatal mortality rate.ResultsAnalysis included 19 301 births during the final 24 months of the intervention. More than one-third of newly pregnant women joined the groups. The neonatal mortality rate was significantly lower in the intervention arm (21.3 neonatal deaths per 1000 live births vs 30.1 per 1000 in control areas), a reduction in neonatal mortality of 38% (risk ratio, 0.62 [95% CI, 0.43-0.89]) when adjusted for socioeconomic factors. The cost-effectiveness was US $220 to $393 per year of life lost averted. Cause-specific mortality rates suggest reduced deaths due to infections and those associated with prematurity/low birth weight. Improvements were seen in hygienic home delivery practices, newborn thermal care, and breastfeeding practices.Conclusions And RelevanceWomen's group community mobilization, delivered at adequate population coverage, is a highly cost-effective approach to improve newborn survival and health behavior indicators in rural Bangladesh.Trial Registrationisrctn.org Identifier: ISRCTN01805825.

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