-
Anesthesia and analgesia · Mar 1989
Aging: effects on minimum alveolar concentration (MAC) for halothane in Fischer-344 rats.
- G E Loss, E Seifen, R H Kennedy, and A B Seifen.
- Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock 72205.
- Anesth. Analg. 1989 Mar 1;68(3):359-62.
AbstractIt is well-established that the anesthetic requirement (MAC) of volatile agents such as halothane is reduced in elderly patients. The current project was designed to determine whether a similar alteration in anesthetic requirement occurs in Fischer-344 (F-344) rats, an animal model often utilized in physiology and pharmacology to examine aging-related changes. Animals were exposed to increasing or decreasing levels of halothane. After equilibration at each concentration, the response to tail-clamping was used for MAC testing. MAC was reduced approximately 17% in aged (25 months) versus young adult (5 months) animals. From these data, it is concluded that the F-344 rat may be an adequate model for examination of age-dependent alterations in the actions of volatile anesthetics.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..