• Nicola S Curry, Ross A Davenport, Beverley J Hunt, and Simon J Stanworth.
• NHS Blood and Transplant, Oxford University Hospitals NHS Trust and University of Oxford, UK. nicola.curry@nhsbt.nhs.uk
• Blood Rev. 2012 Sep 1;26(5):223-32.

AbstractUncontrolled bleeding is the most common preventable cause of death for patients with severe injury. Coagulopathy inevitably accompanies severe bleeding, exacerbated by the ongoing blood loss and the treatments administered. There is debate about the underlying pathophysiological mechanisms of early traumatic coagulopathy and uncertainty about whether injury induces a unique coagulopathy when compared to other forms of major haemorrhage. This review describes current understanding of the coagulopathy of major blood loss and focuses on the early coagulation changes that occur following severe injury. It then reports on the contemporary management of coagulopathic bleeding using new transfusion strategies. Finally this review presents some practical points to the delivery of transfusion for major blood loss in the modern hospital setting.Copyright © 2012 Elsevier Ltd. All rights reserved.

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