• Paul S Myles, Philip Peyton, Brendan Silbert, Jennifer Hunt, John R A Rigg, Daniel I Sessler, and ANZCA Trials Group Investigators.
• Department of Anaesthesia and Perioperative Medicine, Alfred Hospital, Melbourne, Australia. p.myles@alfred.org.au
• BMJ. 2011 Jan 1;342:d1491.

ObjectiveTo compare long term recurrence of cancer and survival of patients having major abdominal surgery for cancer.DesignLong term follow-up of prospective randomised controlled clinical trial in which patients were randomly assigned to receive general anaesthesia with or without epidural block for at least three postoperative days. Setting 23 hospitals in Australia, New Zealand, and Asia.Participants503 adult patients who had potentially curative surgery for cancer.Main Outcome MeasureCancer-free survival (analysis was by intention to treat).ResultsLong term follow-up data were available for 94% (n=446) of eligible participants. The median time to recurrence of cancer or death was 2.8 (95% confidence interval 0.7 to 8.7) years in the control group and 2.6 (0.7 to 8.7) years in the epidural group (P=0.61). Recurrence-free survival was similar in both epidural and control groups (hazard ratio 0.95, 95% confidence interval 0.76 to 1.17; P=0.61).ConclusionUse of epidural block in abdominal surgery for cancer is not associated with improved cancer-free survival.Trial RegistrationAustralian New Zealand Clinical Trials Registry ACTRN12607000637448.

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