• Circ Arrhythm Electrophysiol · Jun 2015

    Randomized Controlled Trial

    Carperitide and atrial fibrillation after coronary bypass grafting: the Nihon University working group study of low-dose HANP infusion therapy during cardiac surgery trial for postoperative atrial fibrillation.

    • Akira Sezai, Mitsuru Iida, Isamu Yoshitake, Shinji Wakui, Shunji Osaka, Haruka Kimura, Hiroko Yaoita, Hiroaki Hata, Motomi Shiono, Toshiko Nakai, Tadateru Takayama, Satoshi Kunimoto, Yuji Kasamaki, and Atsushi Hirayama.
    • From the Departments of Cardiovascular Surgery (A.S., M.I., I.Y., S.W., S.O., H.K., H.Y., H.H., M.S.) and Cardiology (T.N., T.T., S.K., Y.K., A.H.), Nihon University, School of Medicine, Tokyo, Japan. asezai.med@gmail.com.
    • Circ Arrhythm Electrophysiol. 2015 Jun 1;8(3):546-53.

    BackgroundOccurrence of atrial fibrillation after cardiac surgery is associated with long-term mortality. We investigated whether infusion of human atrial natriuretic peptide (carperitide) could prevent postoperative atrial fibrillation.Methods And ResultsA total of 668 patients who underwent isolated coronary artery bypass grafting were randomized to receive infusion of carperitide or physiological saline from the initiation of cardiopulmonary bypass. Patients were monitored continuously for 1 week after surgery to detect atrial fibrillation. The risk factors were investigated by Cox proportional hazard model. Postoperative atrial fibrillation occurred in 41 of 335 patients (12.2%) from the carperitide group versus 110 of 333 patients (32.7%) from the placebo group (P<0.0001). Postoperative levels of angiotensin-II, aldosterone, creatine kinase MB isoenzyme, human heart fatty acid-binding protein, and brain natriuretic peptide were all significantly lower in the carperitide group. The risk factors for postoperative atrial fibrillation by the Cox proportional hazard model were an age ≥70 years, emergency surgery, preoperative aldosterone level >150 ng/mL, preoperative nonuse of angiotensin receptor antagonists, preoperative use of calcium antagonists, postoperative nonuse of β-blockers, postoperative nonuse of aldosterone blockers, and nonuse of carperitide.Conclusions-Perioperative carperitide infusion reduced the occurrence of postoperative atrial fibrillation. Accordingly, carperitide could be a useful option for preventing postoperative atrial fibrillation.Clinical Trial Registration-URL: http://www.umin.ac.jp. Unique Identifier: UMIN000003958.© 2015 American Heart Association, Inc.

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