• Sohit P Kanotra, Evan J Propst, Igor Luginbuehl, Paolo Campisi, Joseph A Fisher, and Vito Forte.
• Department of Otolaryngology-Head and Neck Surgery, University of Toronto, The Hospital for Sick Children, Toronto, Canada.
• Laryngoscope. 2014 Jun 1;124(6):1415-9.

Objectives/HypothesisTo assess the risk of aspiration using a novel valve circuit that dynamically modulates endotracheal tube cuff pressure during the ventilatory cycle using bench and live animal models.Study DesignAnimal model.MethodsThe bench model consisted of a cuffed endotracheal tube inserted into an artificial trachea. Leakage of liquid around the cuff was measured after 4 hours of constant or dynamic modulation of cuff pressure at variable peak end expiratory pressures. In the porcine model, eight animals were ventilated with the modulating valve circuit and compared to eight controls ventilated with a constant cuff pressure (25 cm of water). Aspiration was monitored quantitatively using a pH probe (measured as voltage) and visually using fluoroscopy.ResultsThere was no difference in the amount of fluid leakage around the endotracheal tube cuff in the constant or dynamically modulated pressure-cuff groups in the bench or animal models.ConclusionDynamically modulating endotracheal tube-cuff pressures to minimize tracheal mucosal damage does not increase the tendency to leak around the cuff compared to endotracheal tube cuffs inflated to a constant pressure.Level Of EvidenceN/A.© 2013 The American Laryngological, Rhinological and Otological Society, Inc.

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