• Int J Gynaecol Obstet · Jul 2009

    Randomized Controlled Trial

    Low-dose propofol to prevent nausea and vomiting after laparoscopic surgery.

    • Yoshitaka Fujii and Michiyo Itakura.
    • Department of Anesthesiology, Ushiku Aiwa General Hospital, Ibaraki, Japan. yfujii@med.toho-u.ac.jp
    • Int J Gynaecol Obstet. 2009 Jul 1;106(1):50-2.

    ObjectiveTo evaluate the efficacy of administering a low dose of propofol at the end of surgery in preventing postoperative nausea/vomiting in women undergoing gynecologic laparoscopic surgery.MethodIn a randomized, double-blind, placebo-controlled study, 90 patients received intravenous injections of a placebo or propofol at 2 different low doses, 0.25 mg/kg or 0.5 mg/kg. All episodes of nausea, retching, or vomiting were then recorded for 24 hours.ResultsThe percentages of patients experiencing nausea, retching, or vomiting were 67% in the placebo group, 60% in the propofol 0.25 mg/kg group (P=0.39), and 33% in the propofol 0.5 mg/kg group (P=0.009). A significant difference in the rates of nausea/vomiting was found between the 2 propofol groups (P=0.03). No adverse events attributed to the study drug were observed.ConclusionProphylactic therapy with 0.5 mg/kg of propofol was found to be effective in preventing nausea/vomiting in patients undergoing gynecologic laparoscopic surgery.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…