• J. Neurosci. Res. · Feb 2009

    Review

    Minocycline: a neuroprotective agent for hypoxic-ischemic brain injury in the neonate?

    • Kathryn M Buller, Michelle L Carty, Hanna E Reinebrant, and Julie A Wixey.
    • Perinatal Research Centre, University of Queensland Centre for Clinical Research, Herston, Queensland, Australia. k.buller@uq.edu.au
    • J. Neurosci. Res. 2009 Feb 15;87(3):599-608.

    AbstractMinocycline is a second-generation tetracycline and a potential neuroprotective intervention following brain injury. However, despite the recognized beneficial effects of minocycline in a multitude of adult disease states, the clinical application of minocycline in neonates is contentious. Tetracyclines, as a class, are not usually administered to neonates, but there is compelling evidence that minocycline reduces brain injury after neonatal hypoxic-ischemic brain injury. This Review focuses on the evidence for minocycline use in neonates by considering aspects of pharmacology, drug regimens, functional outcomes, and mechanisms of action.(c) 2008 Wiley-Liss, Inc.

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