• Epilepsia · Jan 1999

    Randomized Controlled Trial Comparative Study Clinical Trial

    Gabapentin monotherapy for the symptomatic treatment of painful neuropathy: a multicenter, double-blind, placebo-controlled trial in patients with diabetes mellitus.

    • M M Backonja.
    • Department of Neurology, University of Wisconsin Medical School, Madison 53792, USA.
    • Epilepsia. 1999 Jan 1;40 Suppl 6:S57-9; discussion S73-4.

    AbstractPain is the most disturbing symptom of diabetic neuropathy. Traditionally this type of pain was treated with tricyclic antidepressants which frequently have many side effects. In the study reported here, gabapentin was administered in escalating doses up to 3600 mg per day to eligible patients with moderate to severe diabetic neuropathy pain in a double blind placebo controlled fashion. Gabapentin provided superior and significant pain relief over placebo. In addition, patients taking gabapentin had improvement of sleep scores and a number of items on mood and quality of life questionnaires. Gabapentin was tolerated well with mild and tolerable side effects.

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