• J. Trop. Pediatr. · Jun 2013

    Randomized Controlled Trial

    Daily and Weekly Iron Supplementations are Effective in Increasing Hemoglobin and Reducing Anemia in Infants.

    • Francisco Plácido Nogueira Arcanjo, Paulo Roberto Santos, Caio Plácido Costa Arcanjo, Silvia Maria Meira Magalhães, and Alvaro Jorge Madeiro Leite.
    • Federal University of Ceara, Sobral Unit, 62042-280 Sobral, Ceara, Brazil. franciscoplacidoarcanjo@gmail.com
    • J. Trop. Pediatr. 2013 Jun 1;59(3):175-9.

    ObjectiveThe objective of this study was to evaluate the effect of daily and weekly iron supplementation compared with control on hemoglobin values and anemia prevalence in infants.MethodsIn this cluster-randomized study, we evaluated infants aged 12-24 months (n = 210) from three public daycare centers, during 4 months. Intervention-group A was allocated 25 mg elemental iron once weekly; intervention-group B received 12.5 mg elemental iron once daily; control-group C received 0.5 ml of a natural color additive. Hemoglobin was assessed before and after intervention.ResultsBaseline mean hemoglobin was 8.81 ± 0.89 g/dl (group A), 9.70 ± 1.56 g/dl (group B) and 10.96 ± 0.92 g/dl (group C); after intervention, mean hemoglobin was 10.03 ± 0.78 g/dl (p < 0.0001), 10.65 ± 0.97 g/dl (p < 0.0001) and 11.30 ± 0.80 g/dl (p = 0.0034) for groups A, B and C, respectively. Anemia prevalence was as follows: group A, 100% at baseline and 83.3% at end of study, p = 0.0001; group, B 75.0% and 41.7%, p = 0.0002; group C, 50.0% and 37.5%, p = 0.182.ConclusionsWeekly and daily iron supplementation were effective in increasing hemoglobin levels and reducing anemia in infants.

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