• A W Oldenbeuving, P L M de Kort, L J Kappelle, C M van Duijn, and G Roks.
• Department of Intensive Care Medicine, St Elisabeth Hospital, Tilburg, The Netherlands. Electronic address: a.oldenbeuving@elisabeth.nl.
• Am J Geriatr Psychiatry. 2013 Oct 1;21(10):935-7.

ObjectiveTo study the association between the epsilon 4 allele of apolipoprotein E (APOEε4) and delirium in a stroke population.Methods527 consecutive stroke patients were screened for delirium during the first week of admission with the confusion assessment method. In three hundred fifty-three patients genomic DNA isolation was available.ResultsThe incidence of delirium after stroke in the 353 patients was 11.3%. There was no association between APOEε4 and delirium. Even after adjustment for IQCODE, stroke localization, stroke subtype, stroke severity, infection, and brain atrophy no association was found (odds ratio: 0.9; 95% confidence interval: 0.4-2.1). Delirium did not last longer in patients with an APOEε4 allele compared to patients without an APOEε4 allele (median: 5.6 days [range: 1-21] versus median: 4.6 days [range: 1-15], p = 0.5).ConclusionThere was no association between the presence of an APOEε4 allele and the occurrence of delirium in the acute phase after stroke.Copyright © 2013 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

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