• Philippe Montravers, Matteo Bassetti, Hervé Dupont, Christian Eckmann, Wolfgang R Heizmann, Xavier Guirao, Miguel Sánchez García, Maria Rita Capparella, Damien Simoneau, and Klaus Friedrich Bodmann.
• Département d'Anesthésie Réanimation, Univ Paris Diderot, Sorbonne Paris Cité and APHP, Centre Hospitalier Universitaire Bichat-Claude Bernard, Paris, France. philippe.montravers@bch.aphp.fr
• J. Antimicrob. Chemother. 2013 Jul 1;68 Suppl 2:ii15-24.

ObjectivesTigecycline is an approved treatment for complicated skin and soft-tissue infections (cSSTIs). The efficacy of tigecycline as monotherapy or in combination with other antibacterials in the treatment of cSSTI in routine practice is described.Patients And MethodsIndividual patient-level data were pooled from five European observational studies (July 2006 to October 2011).ResultsA total of 254 cSSTI patients who received tigecycline were included (mean age 63.2 ± 14.9 years). Of these, 34.4% were in intensive care units, 54.5% acquired their infection in hospital and 90.9% had at least one comorbidity. Infection most commonly affected the limbs (62.4%) and 43.8% of infections were classified as necrotizing. The mean Acute Physiology and Chronic Health Evaluation (APACHE) II and Sequential Organ Failure Assessment (SOFA) scores at the beginning of treatment were 15.0 ± 7.9 (n = 205) and 5.8 ± 3.9 (n = 32), respectively, indicating high disease severity. Staphylococcus aureus (52.7%), Escherichia coli (18.0%) and Enterococcus faecium (12.0%) were the most frequently isolated pathogens; 32.9% of infections were polymicrobial and 30.5% were due to resistant pathogens. Overall, 71.8% received tigecycline as monotherapy and 28.2% as combination therapy for a mean duration of 12 days. Clinical response rates at the end of treatment were 79.6% for all patients who received the standard dosage (183/230), 86.7% for patients who received tigecycline as monotherapy (143/165), 75.0% for patients with a nosocomial infection (96/128), 75.3% for patients with an APACHE II score >15 (61/81) and 58.3% for patients with a SOFA score ≥ 7 (7/12).ConclusionsIn these real-life studies, tigecycline, alone and in combination, achieved favourable clinical response rates in patients with cSSTI with a high severity of illness.

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