• Dae Young Hong, Kim Jong Won JW Department of Emergency Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea., Jin Hui Paik, Hyun Min Jung, Kwang Je Baek, Sang O Park, and Kyeong Ryong Lee.
• Department of Emergency Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea.
• Clin. Chim. Acta. 2016 Jan 15; 452: 177-81.

BackgroundSepsis is a major cause of morbidity and mortality in the emergency department. This study aimed to evaluate the assessment of severity of sepsis by and prognostic value of plasma neutrophil gelatinase-associated lipocalin (NGAL) compared with other widely used biological markers of inflammation in patients with sepsis.MethodsNGAL, procalcitonin, and C-reactive protein values were measured in 470 patients with suspected sepsis, and the Mortality in Emergency Department Sepsis (MEDS) score was obtained for all enrolled subjects, who were followed for up to 28days.ResultsThe median plasma NGAL value was increased with sepsis severity according to the MEDS score. The plasma NGAL value was higher in nonsurvivors than in survivors. The area under the receiver operating characteristic curve of NGAL (0.797) was greater than that of procalcitonin (0.599) and MEDS score (0.774) in predicting 28-day hospital mortality. Multivariable logistic regression found that the plasma NGAL value was an independent predictor for hospital mortality in patients with sepsis. The plasma NGAL values were positively correlated with C-reactive protein and procalcitonin levels, and MEDS scores.ConclusionsPlasma NGAL is a valuable biological marker in the assessment of severity and prediction of prognosis of patients with sepsis in the emergency department.Copyright © 2015 Elsevier B.V. All rights reserved.

33 keywords...

hide…