• Luciane Rezende Costa, Paulo Sucasas Costa, Sarah Vieira Brasileiro, Cristiane Baccin Bendo, Cláudia Marina Viegas, and Saul Martins Paiva.
• Faculty of Dentistry, Universidade Federal de Goiás, Goiânia, Brazil.
• J. Pediatr. 2012 May 1;160(5):807-13.

ObjectiveTo compare the occurrence of post-discharge adverse events in children having received a high dose of either chloral hydrate (CH) or midazolam (MZ) during outpatient dental treatment.Study DesignA repeated-measures study design was carried out with 42 children treated at a sedation center. The sample comprised 103 dental sedation sessions among 22 male and 20 female patients, 1-8 years old, receiving either MZ (1.0-1.5 mg/kg) or CH (70.0-100.0 mg/kg). During treatment, a single observer recorded intraoperative adverse events. Twenty-four hours later, the observer called the child's main caregiver seeking information on further adverse events. Data analysis involved descriptive and bivariate statistics and the general estimating equation for repeated measures.ResultsThe most common intraoperative and post-discharge adverse events were hallucination (3.9%) and excessive sleep (41.9%), respectively. The chance of the occurrence of an adverse event following oral pediatric sedation was lesser among the children who received MZ than those who received CH (OR: 0.09; 95% CI: 0.01-0.88).ConclusionsHigh doses of CH were associated with post-discharge adverse events in children having undergone pediatric dental sedation, whereas high doses of MZ were not associated with these events in pediatric patients.Copyright © 2012 Mosby, Inc. All rights reserved.

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