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Gan To Kagaku Ryoho · Sep 2013
Case Reports[A case of esophageal cancer with septic disseminated intravascular coagulation treated with recombinant human soluble thrombomodulin during chemoradiation therapy].
- Ken Sasaki, Hiroshi Okumura, Yasuto Uchikado, Koji Minami, Tetsuya Ijichi, Tetsuhiro Owaki, Sumiya Ishigami, and Shoji Natsugoe.
- Dept. of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University, Japan.
- Gan To Kagaku Ryoho. 2013 Sep 1;40(9):1213-5.
AbstractA 70-year-old woman was diagnosed with synchronous advanced esophageal cancer and early renal cancer. During chemoradiation therapy for the esophageal cancer, she suffered from septic shock due to pneumonia. She got worse despite the administration of antibiotics and gglobulin. On the following day, she was diagnosed with septic disseminated intravascular coagulation(DIC)on the basis of the diagnostic criterion for acute DIC. Recombinant human soluble thrombomodulin(rTM) was administered to treat the DIC. The patient responded promptly to rTM treatment and recovered from the DIC in just 1 day. rTM is thought to be an effective drug for sepsis-induced DIC during chemoradiation therapy.
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