• Stacey L Valentine, Anil Sapru, Renee A Higgerson, Phillip C Spinella, Heidi R Flori, Dionne A Graham, Molly Brett, Maureen Convery, LeeAnn M Christie, Laurie Karamessinis, Adrienne G Randolph, Pediatric Acute Lung Injury and Sepsis Investigator's (PALISI) Network, and Acute Respiratory Distress Syndrome Clinical Research Network (ARDSNet).
• Critical Care Division, Department of Anesthesia, Perioperative and Pain Medicine, Children's Hospital Boston, and Department of Anesthesia, Harvard Medical School, Boston, MA 02115, USA. stacey.valentine@childrens.havard.edu
• Crit. Care Med.. 2012 Oct 1;40(10):2883-9.

ObjectivesIn the Fluid and Catheter Treatment Trial (NCT00281268), adults with acute lung injury randomized to a conservative vs. liberal fluid management protocol had increased days alive and free of mechanical ventilator support (ventilator-free days). Recruiting sufficient children with acute lung injury into a pediatric trial is challenging. A Bayesian statistical approach relies on the adult trial for the a priori effect estimate, requiring fewer patients. Preparing for a Bayesian pediatric trial mirroring the Fluid and Catheter Treatment Trial, we aimed to: 1) identify an inverse association between fluid balance and ventilator-free days; and 2) determine if fluid balance over time is more similar to adults in the Fluid and Catheter Treatment Trial liberal or conservative arms.DesignMulticentered retrospective cohort study.SettingFive pediatric intensive care units.PatientsMechanically ventilated children (age≥1 month to <18 yrs) with acute lung injury admitted in 2007-2010.InterventionsNone.Measurements And Main ResultsFluid intake, output, and net fluid balance were collected on days 1-7 in 168 children with acute lung injury (median age 3 yrs, median PaO2/FIO2 138) and weight-adjusted (mL/kg). Using multivariable linear regression to adjust for age, gender, race, admission day illness severity, PaO2/FIO2, and vasopressor use, increasing cumulative fluid balance (mL/kg) on day 3 was associated with fewer ventilator-free days (p=.02). Adjusted for weight, daily fluid balance on days 1-3 and cumulative fluid balance on days 1-7 were higher in these children compared to adults in the Fluid and Catheter Treatment Trial conservative arm (p<.001, each day) and was similar to adults in the liberal arm.ConclusionsIncreasing fluid balance on day 3 in children with acute lung injury at these centers is independently associated with fewer ventilator-free days. Our findings and the similarity of fluid balance patterns in our cohort to adults in the Fluid and Catheter Treatment Trial liberal arm demonstrate the need to determine whether a conservative fluid management strategy improves clinical outcomes in children with acute lung injury and support a Bayesian trial mirroring the Fluid and Catheter Treatment Trial.

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