• Anaesthesia · May 1999

    Randomized Controlled Trial Clinical Trial

    Continuous propofol administration for suxamethonium-induced postoperative myalgia.

    • A D Manataki, H M Arnaoutoglou, L K Tefa, G K Glatzounis, and G S Papadopoulos.
    • Department of Anaesthesiology, G. Hatzikosta General Hospital, Ioannina, Greece.
    • Anaesthesia. 1999 May 1;54(5):419-22.

    AbstractThe effect of continuous propofol administration on creatine kinase and suxamethonium-induced postoperative myalgia was evaluated in 50 patients randomised into two groups of 25 patients each. Induction of anaesthesia was identical in all patients. Anaesthesia was maintained with 66% nitrous oxide in oxygen supplemented by either isoflurane 1% or continuous propofol. Creatine kinase was measured before and after operation. Myalgia was evaluated postoperatively by a blinded observer. The median level of myalgia was reduced significantly in the continuous propofol group (p = 0.011). The median creatine kinase value increased significantly in the isoflurane group (from 90 to 160 IU, p = 0.001).

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