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Acta Anaesthesiol Scand · Feb 2000
Randomized Controlled Trial Clinical TrialHaemodynamic effects of intravenous clonidine on propofol or thiopental induction.
- F Marinangeli, C Cocco, A Ciccozzi, A Ciccone, F Donatelli, G Facchetti, A Paladini, A Pasqualucci, and G Varrassi.
- Department of Anaesthesiology, Intensive Care and Pain Management, University of L'Aquila, Coppito, Italy.
- Acta Anaesthesiol Scand. 2000 Feb 1;44(2):150-6.
AbstractThe study evaluated the effects of premedication with intravenous clonidine on thiopental or propofol requirements for induction and haemodynamic changes associated with both induction and endotracheal intubation. Clonidine administered intravenously before induction of anaesthesia reduced propofol or thiopental requirements. The association of clonidine and propofol caused, after injection of the induction drug, a decrease in mean arterial pressure which was significantly greater than with thiopental. Moreover, a major haemodynamic stability was registered before and after laryngoscopy in the clonidine-thiopental group. These findings might contraindicate the clonidine-propofol combination in patients with cardiovascular disease.
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