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Randomized Controlled Trial Clinical Trial
No effect of antiviral (valacyclovir) treatment in fibromyalgia: a double blind, randomized study.
- Sally Aspegren Kendall, Malika Lone Chenoufi Schaadt, Lykke Bjerglund Graff, Irene Wittrup, Hanne Malmskov, Kim Krogsgaard, Else-Marie Bartels, Henning Bliddal, and Bente Danneskiold-Samsøe.
- Parker Institute, Department of Rheumatology, Frederiksberg Hospital, Frederiksberg, Denmark.
- J Rheumatol. 2004 Apr 1;31(4):783-4.
ObjectiveTo investigate the effect of an antiviral compound, valacyclovir, on pain and tenderness in patients with the fibromyalgia (FM) syndrome.MethodsSixty patients were randomized into a double blind, placebo controlled 6 week trial. Primary outcome was pain intensity change (on visual analog scale). Secondary outcome measures were tender points (myalgic score) and Fibromyalgia Impact Questionnaire (FIQ).ResultsFifty-two patients completed the study. The numbers of dropouts due to adverse events were equal in valacyclovir (2) and placebo (2) groups. The effect of valacyclovir on pain and tenderness and FIQ did not differ from placebo.ConclusionValacyclovir cannot be recommended as a therapy for FM at this point.
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