• Homer C N Tien, Lorraine N Tremblay, Sandro B Rizoli, Jacob Gelberg, Talat Chughtai, Peter Tikuisis, Pang Shek, and Frederick D Brenneman.
• Trauma Program, and Department of Surgery, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, Canada. homer.tien@sw.ca
• Arch Surg Chicago. 2006 Dec 1;141(12):1185-91; discussion 1192.

HypothesisAdmission blood alcohol concentration (BAC) is associated with in-hospital death in patients with severe brain injury from blunt head trauma.DesignRetrospective cohort study.SettingAcademic level I trauma center in Toronto, Ontario.PatientsUsing trauma registry data, between January 1, 1988, and December 31, 2003, we identified 1158 consecutive patients with severe brain injury from blunt head trauma.InterventionThere was no active intervention. The primary exposure of interest was the BAC at admission, stratified into the following 3 levels: 0, no BAC; 0 to less than 230 mg/dL, low to moderate BAC; and 230 mg/dL or greater, high BAC.Main Outcome MeasureIn-hospital death.ResultsIn patients with severe brain injury, low to moderate BAC was associated with lower mortality than was no BAC (27.9% vs 36.3%; P = .008). High BAC was associated with higher mortality than was no BAC (44.7% vs 36.3%), although this was not statistically significant (P = .10). These associations were all statistically significant after adjusting for demographic data and injury factors using logistic regression analysis. The odds ratio for death was 0.76 (95% confidence interval, 0.52-0.98) for low to moderate BAC compared with no BAC. The odds ratio for death was 1.73 (95% confidence interval, 1.05-2.84) for high BAC compared with no BAC.ConclusionsLow to moderate BAC may be beneficial in patients with severe brain injury from blunt head trauma. In contrast, high BAC seems to have a deleterious effect on in-hospital death in these patients, which may be related to its detrimental hemodynamic and physiologic effects. Alcohol-based fluids may have a role in the management of patients with severe brain injury after they have been well resuscitated.

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