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- Russell P Bowler.
- Department of Medicine, National Jewish Health, Denver, CO, USA. bowlerr@njhealth.org
- COPD. 2012 Dec 1;9(6):651-3.
AbstractClinical research in chronic obstructive pulmonary disease (COPD) has been hampered by the lack of validated blood biomarkers. The ideal COPD biomarker would have the following characteristics: (1) it would be a lung specific protein that could be assayed in blood; (2) it would change with disease severity or during exacerbations; (3) it would be specific for COPD; and would be responsive to change with effective treatments. One such candidate is the lung specific protein surfactant protein D (SP-D). In this review, we discuss the evidence supporting SP-D as a COPD biomarker.
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