• Saad Nseir, Christophe Di Pompeo, Stéphane Soubrier, Hélène Lenci, Pierre Delour, Thierry Onimus, Fabienne Saulnier, Daniel Mathieu, and Alain Durocher.
• Regional University Centre, Calmette Hospital, EA 3614, Lille II University, Lille, France. s-nseir@chru-lille.fr
• Crit Care. 2005 Jun 1;9(3):R238-45.

IntroductionOur objective was to determine the effect of ventilator-associated tracheobronchitis (VAT) on outcome in patients without chronic respiratory failure.MethodsThis was a retrospective observational matched study, conducted in a 30-bed intensive care unit (ICU). All immunocompetent, nontrauma, ventilated patients without chronic respiratory failure admitted over a 6.5-year period were included. Data were collected prospectively. Patients with nosocomial pneumonia, either before or after VAT, were excluded. Only first episodes of VAT occurring more than 48 hours after initiation of mechanical ventilation were studied. Six criteria were used to match cases with controls, including duration of mechanical ventilation before VAT. Cases were compared with controls using McNemar's test and Wilcoxon signed-rank test for qualitative and quantitative variables, respectively. Variables associated with a duration of mechanical ventilation longer than median were identified using univariate and multivariate analyses.ResultsUsing the six criteria, it was possible to match 55 (87%) of the VAT patients (cases) with non-VAT patients (controls). Pseudomonas aeruginosa was the most frequently isolated bacteria (34%). Although mortality rates were similar between cases and controls (29% versus 36%; P = 0.29), the median duration of mechanical ventilation (17 days [range 3-95 days] versus 8 [3-61 days]; P < 0.001) and ICU stay (24 days [range 5-95 days] versus 12 [4-74] days; P < 0.001) were longer in cases than in controls. Renal failure (odds ratio [OR] = 4.9, 95% confidence interval [CI] = 1.6-14.6; P = 0.004), tracheostomy (OR = 4, 95% CI = 1.1-14.5; P = 0.032), and VAT (OR = 3.5, 95% CI = 1.5-8.3; P = 0.004) were independently associated with duration of mechanical ventilation longer than median.ConclusionVAT is associated with longer durations of mechanical ventilation and ICU stay in patients not suffering from chronic respiratory failure.

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