• Ji Su Jang, Jun Ho Lee, Jae Jun Lee, Won Jae Park, Sung Mi Hwang, Soo Kyung Lee, and So Young Lim.
• Department of Anesthesiology and Pain Medicine, School of Medicine, Hallym University, Chuncheon 200-704, Korea.
• Yonsei Med. J. 2012 Sep 1;53(5):1010-3.

PurposeThis prospective study evaluated the effects of continuous sedation using midazolam, with or without remifentanil, on postoperative nausea and vomiting (PONV) in patients undergoing myringoplasty.Materials And MethodsSixty patients undergoing myringoplasty were sedated with midazolam in the presence of remifentanil (group MR), or after saline injection instead of remifentanil (group M).ResultsThree patients (10%) in group M complained of nausea; two vomited. Four patients (13%) in group MR complained of nausea and vomited within 24 h after surgery. Rescue drugs were given to the six patients who vomited. No significant difference was detected between the two groups regarding the incidence or severity of nausea, incidence of vomiting, or need for rescue drugs.ConclusionMidazolam-based continuous sedation can reduce PONV after myringoplasty. Compared with midazolam alone, midazolam with remifentanil produced no difference in the incidence or severity of nausea, incidence of vomiting, or need for rescue drugs.

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