• J. Am. Acad. Dermatol. · Aug 1998

    Chronic neuropathic symptoms after exposure to mustard gas: a long-term investigation.

    • A B Thomsen, J Eriksen, and K Smidt-Nielsen.
    • H:S Multidisciplinary Pain Center, National Hospital, Department 7122, Copenhagen, Denmark.
    • J. Am. Acad. Dermatol. 1998 Aug 1;39(2 Pt 1):187-90.

    BackgroundLong-term investigations of persons exposed to mustard gas are few and have primarily focused on its carcinogenic properties. To our knowledge neuropathic pain has never been described.ObjectiveWe investigated late symptoms in the skin after exposure to sulfur mustard.MethodsFive patients exposed to mustard gas during battlefield operations in the Middle East and five fishermen accidentally exposed to sulfur mustard by pulling shells leaking the chemical agent aboard their fishing vessels participated in this study. Clinical examination of the patients from the Middle East and telephone interviews with the fishermen were performed.ResultsAll patients suffered from neuropathic pain or other deafferentation symptoms.ConclusionPersistent damage to the afferent nerve system resulting in chronic neuropathic symptoms is probably a frequent complication in persons exposed to mustard gas.

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