• Lars Hüter, Konrad Schwarzkopf, Niels-Peter Preussler, Elke Gaser, Harald Schubert, Waheedullah Karzai, and Torsten Schreiber.
• Department of Anaesthesiology and Intensive Care Medicine, University of Jena, Jena, Germany.
• J. Cardiothorac. Vasc. Anesth. 2004 Apr 1; 18 (2): 190-3.

ObjectiveThe agreement between cardiac output measurements via pulmonary artery thermodilution (CO[PA]) and transpulmonary aortic thermodilution (CO[AT]) during one-lung ventilation was studied.DesignAnimal study with repeated simultaneous measurements comparing 2 cardiac output measurement techniques.SettingExperimental animal facility of a university department.ParticipantsForty-eight female pigs (26-42 kg).InterventionsThe pigs were anesthetized, tracheally intubated, and mechanically ventilated. After placement of an aortic thermistor catheter via the femoral artery and a pulmonary artery catheter, a double-lumen tube was placed via tracheotomy. During one-lung ventilation in each animal, 3 measurements with pulmonary artery thermodilution and transpulmonary aortic thermodilution were performed in different hemodynamic states. Both thermistors were connected to 1 computer system, and 144 simultaneous cardiac output measurements were analyzed.Measurements And Main ResultsLinear regression analyses revealed a close relationship between the 2 methods: CO(AT) = 0.81 CO(PA) + 1.04 (L/min) (r = 0.96, p < 0.0001). Bland-Altman analysis showed that CO(AT) was slightly higher than the CO(PA) with a bias of 0.2 +/- 0.5 L/min. However, in higher CO states, an inversion of this relationship was found, possibly because of indicator loss and recirculation.ConclusionsThe pulmonary artery thermodilution and the transpulmonary aortic thermodilution techniques both accurately measure cardiac output during one-lung ventilation.

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