• Langenbecks Arch Surg · Mar 1998

    Review

    Molecular mechanisms of sepsis.

    • A Woltmann, L Hamann, A J Ulmer, J Gerdes, H P Bruch, and E T Rietschel.
    • Research Center Borstel, Centre for Medicine and Biosciences, Germany.
    • Langenbecks Arch Surg. 1998 Mar 1;383(1):2-10.

    AbstractToday a great number of problems in the field of bacterial sepsis remain to be solved. Understanding the molecular mechanisms of one of the most important bacterial products in the pathogenesis of sepsis - endotoxin may contribute to innovative and more effective therapies. Therefore, this review focuses on the structural and functional elements of endotoxin, its interaction with immune cells, and its biological activity. Finally, other bacterial components and their impact on sepsis are discussed.

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