• Clin Transl Sci · Oct 2009

    Review

    Thrombotic microangiopathies: multimers, metalloprotease, and beyond.

    • Joel Moake.
    • Rice University, Houston, Texas, USA. jmoake@rice.edu
    • Clin Transl Sci. 2009 Oct 1;2(5):366-73.

    AbstractThe pathophysiology of various types of thrombotic microangiopathies is coming progressively into focus. Therapeutic advances are likely to follow at a quickening pace. This discussion focuses on thrombotic thrombocytopenic purpura (TTP), the hemolytic-uremic syndrome (HUS), thrombotic microangiopathies associated with transplantation-immunosuppression or anti-angiogenesis therapy, and the preeclampsia/hemolysis-elevated liver enzymes and low platelets syndrome (HELLP).

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