• Masui · Sep 2009

    Review

    [Serotonin receptor gene polymorphism and analgesic sensitivity].

    • Jun Aoki, Kazutaka Ikeda, and Kazuhiko Iwahashi.
    • Laboratory of Neurophysiology, Graduate School of Environmental Health Sciences, Azabu University, Sagamihara 229-8501.
    • Masui. 2009 Sep 1;58(9):1130-5.

    AbstractThere are gene polymorphisms changing the expression or activation of the serotonin (5-HT) receptors, which are associated with pain. This review showed an availability of 5-HT2A receptor gene polymorphism in analgesic sensitivity. To search gene polymorphisms related to analgesic sensitivity is important to further effective pain management. In future 5-HT2A receptor gene polymorphisms, together with polymorphisms of other genes, may greatly contribute to effective postoperative pain management and personalized medicine.

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