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Ned Tijdschr Geneeskd · Apr 2007
Case Reports[Risk of acute hepatic insufficiency in children due to chronic accidental overdose of paracetamol (acetaminophen)].
- P Hameleers-Snijders, M Hogeveen, J A M Smeitink, C Kramers, and J M Th Draaisma.
- Afd. Kindergeneeskunde, Universitair Medisch Centrum St Radboud, Postbus 6101, 6500 HB Nijmegen. p.hameleers@cukz.umcn.nl
- Ned Tijdschr Geneeskd. 2007 Apr 21;151(16):897-900.
AbstractTwo girls aged 4 and 3 years, respectively, experienced acute liver failure due to accidental ingestion of supratherapeutic doses of paracetamol (90 mg/kg/day or more). Recognition of chronic paracetamol intoxication as a cause of acute hepatic failure is often delayed. It is important to consider the possibility of paracetamol-induced hepatotoxicity because many patients will recover if treated with N-acetylcysteine, as did both of these children. Patients with acute liver failure due to chronic paracetamol intoxication present with very high transaminase levels (> 4000 U/l), disproportionately low total bilirubin levels (< 200 micromol/l) and often hypoglycaemia.
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