• Blood Transfus Italy · Apr 2013

    An investigation of the spectrum of common and rare inherited coagulation disorders in north-eastern Iran.

    • Hassan Mansouritorghabeh, Lida Manavifar, Abdollah Banihashem, Alireza Modaresi, Abbas Shirdel, Masoud Shahroudian, Ghazaleh Shoja-E-Razavi, Hamid Pousti, and Habibollah Esmaily.
    • Allergy Research Centre, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. mansouritorghabeh@mums.ac.ir
    • Blood Transfus Italy. 2013 Apr 1;11(2):233-40.

    BackgroundHealth care officials and legislators need accurate data on prevalence and numbers of individuals with bleeding disorders in order to plan and allot their budgets; the manufacturers of coagulation factors also need these data to estimate the amount of factors required to prevent scarcity of these products.Materials And MethodsWe surveyed the prevalence of haemophilia A, haemophilia B, von Willebrand's disease and rare bleeding disorders in North-Eastern Iran. The survey was done in the period from September 2009 to March 2011. Information was collected from the medical records in three major hospitals and a haemophilia centre; the patients' updated data were obtained by telephone.ResultsOverall in the current survey 552 patients with inherited coagulation disorders were identified and their medical records obtained. Of these, 429 (77.5%) had common bleeding disorders (haemophilia A, haemophilia B, von Willebrand's disease), 85 (15.6%) had rare bleeding disorders (deficiency of coagulation factors V, VII, X, XIII, I, XI, combined factor V and VIII deficiency) and 38 (6.9%) had platelet disorders.The commonest bleeding disorders were haemophilia A (n=287, 51.9%), haemophilia B (n=92, 16.6%), von Willebrand's disease (n=50, 9%), factor V deficiency (n=21, 3.8%), factor VII deficiency (n=19, 3.4%), factor X deficiency (n=2, 0.36%), combined factor V and VIII deficiency (n=28, 5.8%), factor XIII deficiency (n=11, 1.99%), factor XI deficiency (n=2, 0.4%), afibrinogenaemia (n=2, 0.36%) and platelet disorders (n=38, 6.9%).DiscussionThere is notable population of individuals with bleeding disorders in North-Eastern Iran.

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